Vc-MMAD, ≥99%

??【編號】：125316

??【產(chǎn)品名稱】：Vc-MMAD, ≥99%

??【規(guī)格】：5MG

??【用途】：

　　Vc-MMAD, ≥99%

　　Product Name： Vc-MMAD

　　CAS號：1401963-17-4

　　分子式：C70H104N12O14S

　　分子量：1369.71

　　貯存：儲存溫度-20°C

　　可溶性： 25°C： DMSO

　　生化和生理學(xué)機(jī)理：

　　Description：

　　Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload and antibody drug conjugate.

　　For comparison purposes, the ADC A1 -mc-MMAD and/or A1 -vc-MMAD were used. The linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule. The linker payload mc- Val-Cit-PABA-MMAD or vc-MMAD (maleimidocapronic -valine-citruline-p- aminobenzyloxycarbonyl- monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule (Antibody-drug conjugates Patent： WO 2013068874 A1).

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Vc-MMAD, ≥99%

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Vc-MMAD, ≥99%

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　　Vc-MMAD, ≥99%

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