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        UNC1215, ≥99%
        ??【編號】:125324

        ??【產品名稱】:UNC1215, ≥99%

        ??【規格】:5MG

        ??【用途】:

          UNC1215, ≥99%

          Product Name: UNC1215
          CAS號:1415800-43-9
          分子式:C32H43N5O2
          分子量:529.72
          貯存: 儲存溫度-20°C
          可溶性: 25°C: DMSO
          生化和生理學機理:
          Description:
          IC50 Value: 120 nM [1]
          UNC1215 is a potent and selective chemical probe for the methyllysine (Kme) reading function of L3MBTL3, a member of the malignant brain tumor (MBT) family of chromatin-interacting transcriptional repressors.
          in vitro: UNC1215 binds L3MBTL3 with a K(d) of 120 nM, competitively displacing mono- or dimethyllysine-containing peptides, and is greater than 50-fold more potent toward L3MBTL3 than other members of the MBT family while also demonstrating selectivity against more than 200 other reader domains examined. X-ray crystallography identified a unique 2:2 polyvalent mode of interaction between UNC1215 and L3MBTL3. In cells, UNC1215 is nontoxic and directly binds L3MBTL3 via the Kme-binding pocket of the MBT domains. UNC1215 increases the cellular mobility of GFP-L3MBTL3 fusion proteins, and point mutants that disrupt the Kme-binding function of GFP-L3MBTL3 phenocopy the effects of UNC1215 on localization [1].
          in vivo: N/A
          Toxicity: N/A
          Clinical trial: N/A
        上一篇:他扎羅汀,≥98% 下一篇:Vc-MMAD, ≥99%



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