VcMMAE, ≥99%

??【編號】：125591

??【產(chǎn)品名稱】：VcMMAE, ≥99%

??【規(guī)格】：1MG

??【用途】：

　　VcMMAE, ≥99%

　　Product Name： VcMMAE

　　CAS號：646502-53-6

　　分子式：C68H105N11O15

　　分子量：1316.63

　　貯存：儲存溫度-20°C

　　可溶性： DMSO

　　生化和生理學(xué)機理：

　　VcMMAE is an antibody-drug conjugate (ADC) with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). Antibody-drug conjugates (ADCs) are designed to combine the exquisite specificity of antibodies to target tumor antigens with the cytotoxic potency of chemotherapeutic drugs. In vivo studies demonstrated that the peptide-linked conjugates induced regressions and cures of established tumor xenografts with therapeutic indices as high as 60-fold. These conjugates illustrate the importance of linker technology, drug potency and conjugation methodology in developing safe and efficacious mAb-drug conjugates for cancer therapy.

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VcMMAE, ≥99%

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VcMMAE, ≥99%

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