白介素18（人類rDNA衍生）（WHO參考試劑）

??【編號】：NIBSC03/200

??【名稱】：白介素18（人類rDNA衍生）（WHO參考試劑）

??【規格】：1ml

??【價格】：2600元

　　Interleukin - 18 (Human rDNA derived)(WHO Reference Reagent)標準品

　　編號：NIBSC03/200

　　中文：白介素18

　　規格：1ml

　　描述：白細胞介素18（人類rDNA衍生）（WHO參考試劑）

　　類型：國際參考試劑

　　描述：1. INTENDED USE

This standard is the primary biological standard fort Interleukin-18 (IL-18).

2. CAUTION

This preparation is not for administration to humans or animals in

the human food chain.

The preparation contains material of human origin, and either the final

product or the source materials, from which it is derived, have been

tested and found negative for HBsAg, anti-HIV and HCV RNA. As with

all materials of biological origin, this preparation should be regarded as

potentially hazardous to health. It should be used and discarded

according to your own laboratory's safety procedures. Such safety

procedures should include the wearing of protective gloves and

avoiding the generation of aerosols. Care should be exercised in

opening ampoules or vials, to avoid cuts.

3. UNITAGE

In a limited collaborative study, the preparation coded 03/200 was found

to possess IL-18 activity comparable to in-house standards, based on its

ability to stimulate release of IFN-gamma from a human myelomonocytic

cell line. The preparation is therefore established as the WHO Reference

Reagent for IL-18 for bioassay, with an assigned potency of 10,000 Units

per ampoule. It should be noted that this assigned potency is arbitrary,

and does not reflect any pre-existing units for IL-18 activity, and it does not

establish continuity with any pre-existing in-house standards. Users of the

material should also note that the preparation 03/200 may be suitable to

serve as a standard for the bioassay of IL-18 using assay methods based

on other biological activities of IL-18, but such applications have not been

demonstrated for 03/200, and would require appropriate validation. Users

who have data supporting the use of this preparation in another biological

assay are encouraged to contact NIBSC.

The preparation 03/200 was also shown to possess immunoactivity

comparable to in-house IL-18 standards, in a limited number of in-house

immunoassay systems. Whilst 03/200 is not formally established as an

immunoassay standard, it may be suitable as an immunoassay standard,

subject to appropriate validation. Users should note particularly that the

immunological stability of this preparation, stability after freezing and

thawing of the reconstituted ampoule contents has not been

demonstrated for all immunoassay systems, and such studies should be

undertaken by the user as part of such immunoassay application

validation.

4. CONTENTS

Country of origin of biological material: United Kingdom.

Each ampoule contains the residue after freeze-drying of 1.0 ml of a

solution comprising:

IL-18 approximately 1 microgram

9.0 mg sodium chloride

1.0 mg trehalose

2.0 mg human serum albumin

0.1 microlitre Tween 20

The IL-18 protein was expressed in E.coli

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Interleukin - 18 (Human rDNA derived)(WHO Reference Reagent)標準品

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