姜黃素, AR
| ??【編號(hào)】：110683 ??【產(chǎn)品名稱】：姜黃素, AR ??【規(guī)格】：5g ??【用途】：   姜黃素, AR
Product Name： Curcumin
別名：姜黃素 ;天然黃3，二阿魏酸甲烷，（E,E）-1，7-雙（4-羥基-3-甲氧基苯基）-1，6-庚二烯-3，5-二酮姜黃素
CAS號(hào)：458-37-7
分子式：C21H20O6
分子量：368.38
介紹： 易溶于冰乙酸，能溶于醇，不溶于醚帶淡綠色熒先，溶于堿呈紅棕色，加酸于堿液后變?yōu)榈S色并析出姜黃素沉淀，溶于濃硫酸帶黃紅色，不溶于水。
用途： 酸堿指示劑，pH7.8(黃)～9.2(紅棕)。顯色反應(yīng)測(cè)鈹、鋯和鎂，硼酸鹽和試劑。 一種天然酚性物質(zhì)，抗腫瘤和消炎物質(zhì)，并具有抗氧化特性，能誘導(dǎo)癌細(xì)胞凋亡。
熔點(diǎn)： 183℃
特定比重： 0.93
生化和生理學(xué)機(jī)理：
Description：
IC50 Value： N/A
Curcumin is a natural phenolic compound with impressive antioxidant properties. Curcumin is recently proved to exert its chemopreventive effects partly through the activation of nuclear factor (erythroid-2 related) factor 2 (Nrf2) [1]. Curcumin possesses chemopreventive properties against several types of cancer, but the molecular mechanisms by which it induces apoptosis of cancer cells and inhibits cancer cell proliferation are not clearly understood.
in vitro： curcumin induced the expression of forkhead box protein O1 (FOXO1) through activation of extracellular signal-regulated kinase 1/2 signaling. Curcumin inhibited cell proliferation, which was associated with upregulation of the cyclin-dependent kinase inhibitors, p27 and p21, and downregulation of cyclin D1 [2]. Treatment of AGS and HT-29 cells with curcumin enhanced the cleavage of procaspase-3, -7, -8 and -9. Meanwhile, curcumin induced endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells [3]. Curcumin upregulated protein level of NF-kappaB inhibitor IkappaBalpha and downregulated protein levels of c-Jun and AR in prostate cancer cell line [5].
in vivo： Chronic treatment with curcumin significantly reversed the CMS-induced behavioral abnormalities (reduced sucrose preference and decreased locomotor activity) in stressed rats. Additionally, curcumin effectively inhibited cytokine gene expression at both the mRNA and the protein level and reduced the activation of NF-κB [4].
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