卡弗他丁C, 90%
| ??【編號】：102376 ??【產品名稱】：卡弗他丁C, 90% ??【規格】：0.1mg ??【用途】：   卡弗他丁C, 90%
Product Name： Calphostin C from Cladosporium cladosporioides
別名：抑制劑C
CAS號：121263-19-2
分子式：C44H38O14
分子量：790.76
介紹： Calphostin C is a novel, cell permeable, potent and highly selective inhibitor of protein kinase C (IC50=0.05 μM). Calphostin C has been shown to compete at the DAG binding site and inhibit DGK (DAG kinase, DAGK). Calphostin inhibition of PKC is light dependent. At higher concentrations it inhibits myosin light chain kinase, PKA (cAMP-dependent protein kinase), protein kinase G, c-Src (pp60v-src protein TyK) (tyrosine kinase) and DGK. This compound also inhibits PC-PLD1 and -PLD2 (Phospholipase D1 and D2, PLD1 and PLD2). Calphostin C has been observed to induce apoptotic DNA fragmentation and cell death. This compound has demonstrated the ability to inhibit cardiac L-type Ca2+ channels. It has demonstrated the ability to Inhibit cardiac L-type calcium channel protein inhibitors. Calphostin C is an inhibitor of MYLK, PKA and PKD.
用途： 蛋白激酶C（IC50=50 nM）的高度特異性抑制劑;需要光進行激活。在較高濃度下（100 nM或更大），它已被證明在體外能抑制細胞增殖和誘導細胞凋亡。
特定比重： 1.48
貯存： 儲存溫度：-20℃
可溶性： Soluble in ethanol (1 mg/ml), DMSO (1 mg/ml), and DMF (1 mg/ml). Insoluble in water., Soluble in ethanol (1 mg/ml), DMSO (1 mg/ml), and DMF (1 mg/ml). Insoluble in water.
生化和生理學機理： Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC50 ~ 40 - 60 nM). Also an antagonist of the Tcf/β-catenin complex.
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