Valspodar, ≥98%
| ??【編號】：127307 ??【產品名稱】：Valspodar, ≥98% ??【規格】：5MG ??【用途】：   Valspodar, ≥98%
Product Name： Valspodar
CAS號：121584-18-7
分子式：C63H111N11O12
分子量：1214.62
貯存： 儲存溫度-20°C
可溶性： DMSO
生化和生理學機理：
Valspodar is a P-glycoprotein (P-gp) inhibitor widely used in preclinical and clinical studies for overcoming multidrug resistance (MDR). In rat, Valspodar showed properties of low hepatic extraction and wide distribution, similar to that of its structural analogue cyclosporine A. Administration of Valspodar to animals before mitoxantrone treatment increased the accumulation of mitoxantrone in the MDR tumors to 94% of that in the wild-type tumors. These studies have added direct in vitro and in vivo visual information on how P-gp processes anticancer compounds and how P-gp inhibitors modulate MDR in resistant cancer cells.
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