PF-04447943
| ??【編號】：127232 ??【產品名稱】：PF-04447943 ??【規格】：5MG ??【用途】：   PF-04447943
Product Name： PF-04447943
CAS號：1082744-20-4
分子式：C20H25N7O2
分子量：395.46
貯存： 儲存溫度-20°C
可溶性： DMSO
生化和生理學機理：
PF-04447943 is a potent, selective brain penetrant PDE9 inhibitor that increased indicators of hippocampal synaptic plasticity and improved cognitive function in a variety of cognition models in both rats and mice. PF-04447943 was found to have high affinity (Ki of 2.8, 4.5 and 18 nM) for human, rhesus and rat recombinant PDE9 respectively and high selectivity for PDE9 versus PDEs1-8 and 10-11. Inhibition of phosphodiesterase 9 (PDE9) has been reported to enhance rodent cognitive function and may represent a potential novel approach to improving cognitive dysfunction in Alzheimer's disease.
|
| 上一篇：普拉西坦，≥99％ | 下一篇：PSI-6206, ≥98% |
|---|
熱銷產品 新品上架
產品推薦 相關產品