Salubrinal, ≥98%

??【編號】：125512

??【產(chǎn)品名稱】：Salubrinal, ≥98%

??【規(guī)格】：5MG

??【用途】：

　　Salubrinal, ≥98%

　　Product Name： Salubrinal

　　別名：2-Propenamide, 3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-, (2E)-

　　CAS號：405060-95-9

　　分子量：479.81

　　貯存：儲存溫度-20°C

　　敏感性：對光敏感

　　可溶性：

　　DMSO 96 mg/mL

　　Water <1 mg/mL

　　Ethanol 2 mg/mL

　　生化和生理學(xué)機(jī)理：

　　Salubrinal, a selective inhibitor of eukaryotic translation initiation factor 2 subunit α (eIF2α) dephosphorylation, on apoptotic cell death and ER stress-signaling events in HK-2 human renal proximal tubular cells exposed to cadmium chloride (CdCl2). Salubrinal suppressed CdCl2-induced cellular damage and cell death. The resulting maintenance of protein phosphorylation results in enhanced protection from the adverse effects of initiators of the unfolded protein response. Salubrinal can also interact with the anti-apoptotic protein Bcl-2, inhibiting binding of the non-peptidic antagonist HA14-1 and of a porphycene that can catalyze Bcl-2 photodamage. As a result, salubrinal offers protection from the apoptotic and autophagic effects that can result from loss of Bcl-2 function. Treatment with salubrinal reduced the number of TUNEL-positive cells and the cleavages of caspase-3 and poly(ADP-ribose) polymerase, but not the cleavage of light chain 3B, indicating

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Salubrinal, ≥98%

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Salubrinal, ≥98%

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　　Salubrinal, ≥98%

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