SJB2-043

??【編號】：126106

??【產(chǎn)品名稱】：SJB2-043

??【規(guī)格】：5MG

??【用途】：

　　SJB2-043

　　Product Name： SJB2-043

　　CAS號：63388-44-3

　　分子式：C17H9NO3

　　分子量：275.26

　　貯存：儲存溫度-20°C

　　可溶性： 25°C： DMSO

　　生化和生理學(xué)機理：

　　Description：

　　IC50 Value： 0.544 uM (USP1) [1]

　　SJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor.

　　Cells were treated with SJB2-043 for 24 hrs and cell extracts were incubated with HA-Ub-VS, followed by immunoblotting with anti-USP1 or anti-HA antibodies. Consistent with our previous studies and the most recent studies by Piatkov et al (24, 31, 33), USP1 in the untreated cells was detected on western blot as a doublet; full length USP1 and an auto-cleaved USP1 with only N-terminus. The Ub-USP1 conjugates were generated in the untreated cell lysates and were detected by an increase in molecular weight of USP1. However, the formation of the Ub-USP1 conjugate was inhibited by the addition of SJB2-043. Ub-aldehyde, a potent known nonspecific DUB inhibitor, caused a complete loss of USP1-Ub-VS conjugates in this competition assay. SJB2-043 inhibited the Ub-VS labeling of a limited number of

上一篇：Palbociclib, ≥99%		下一篇：他卡西醇，≥98％

SJB2-043

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SJB2-043

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