PR-619, ≥99%

??【編號】：126704

??【產(chǎn)品名稱】：PR-619, ≥99%

??【規(guī)格】：25MG

??【用途】：

　　PR-619, ≥99%

　　Product Name： PR-619

　　CAS號：2645-32-1

　　分子量：223.28

　　介紹： PR-619

　　貯存：儲存溫度-20°C

　　可溶性： 25°C： DMSO 45 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL

　　生化和生理學(xué)機(jī)理：

　　Description：

　　IC50 Value： 3.93 μM (EC50, USP4); 7.2 μM (EC50, USP2 core); 5.10 μM (EC50, USP20) [1]

　　PR-619 is a broad-range DUB inhibitor with potential for further development as a chemotherapeutic agent in cancer therapy.

　　in vitro： PR-619 induces HCT116 cell death with EC50 values of 6.3 μM [1]. The general deubiquitylase (DUB) inhibitor, PR-619 attenuated KCa3.1 degradation, indicative of deubiquitylation being required for lysosomal delivery [2]. Proteasome inhibition by MG-132 and deubiquitinase inhibition by PR-619 induces significant changes to the ubiquitin landscape, but that not all ubiquitination sites regulated by MG-132 and PR-619 are likely substrates for the ubiquitin-proteasome system [3]. Cells were incubated with PR-619, a broad-range, reversible inhibitor of ubiquitin isopeptidases. Incubation with PR-619 led to morphological changes, the upregulation of heat shock proteins (HSP), including HSP70 and αB-crystallin, andwww.atcc360.com

上一篇：Edoxaban, ≥99%		下一篇：齊留通，≥98％（HPLC）

PR-619, ≥99%

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PR-619, ≥99%

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